Volume 15, Issue 1 ( March 2023 2023)                   Iranian Journal of Blood and Cancer 2023, 15(1): 36-52 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Shahabi Satlsar E, Anvari S, Sotoudeh F, Mirpour Hassankiadeh S H, Rastgar A, Kheyrandish S. Angioimmunoblastic T-cell lymphoma associated with leukocytosis and lymphocytosis; a case report and systematic review. Iranian Journal of Blood and Cancer 2023; 15 (1) :36-52
URL: http://ijbc.ir/article-1-1356-en.html
Angioimmunoblastic T-cell lymphoma associated with leukocytosis and lymphocytosis; a case report and systematic review
Esmaeil Shahabi Satlsar1 , Saeid Anvari2 , Fatemeh Sotoudeh3 , Seyed Hossein Mirpour Hassankiadeh4 , Amirhossein Rastgar5 , Setare Kheyrandish * 6
1- Clinical laboratory sciences department, School of Paramedical Sciences, Guilan University of Medical Sciences, Rasht, Iran
2- Regenerative medicine, organ procurement and transplantation multi-disciplinary center, Razi hospital, school of medicine, Guilan university of medical sciences, Rasht, Iran; drsaeidanvari@gmail.com
3- Student research committee, school of paramedical sciences, Guilan university of medical sciences, Rasht, Iran
4- Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran;
5- Department of Hematology and Blood Banking, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
6- Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , 7masterstar@gmail.com
Abstract:   (824 Views)

Background: Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon lymphoma arising from follicular T-helper cells. Since this is a rare disease, diagnosis is unfortunately difficult. AITL responds to treatments, therefore by reviewing the characteristics of the available cases, we aimed to classify the available data for in-time diagnosis.
Objectives and data sources: A systematic search was performed on PubMed, Scopus, and Web of Science to January 5, 2023, to investigate the presence of peripheral blood lymphocytosis and leukocytosis in AITL cases.
Results: Among 129 papers, 41 articles with 46 cases were included. All 41 studies were checked in terms of quality by two independent reviewers using an eight-item Joanna Briggs Institute checklist for case report studies. We also reported a 57-year-old Iranian woman with AITL suspected rash. Complete blood count (CBC) analysis showed a significant lymphocytosis and leukocytosis of 26 and 37.5 × 109 /L, respectively.
Conclusion: In the reviewed cases, male predominance was obvious. Lymphadenopathy was the most seen clinical presentation. Dermal abnormalities were presented in more than half of the patients. The prevalence of blood eosinophilia was also remarkable; CD3 and CD4 were expressed the most and CD7, CD8, CD30, and CD56 the least. Despite treatment, the mortality rate was high. In this systematic review, we tried to provide a complete classified review of all AITL cases with different types of leukocytosis to avoid future miss diagnosis of this rare lymphoma.

Keywords: Angioimmunoblastic T-cell lymphoma, Immunoblastic Lymphadenopathy, Leukocytosis, Lymphocytosis
Full-Text [PDF 1045 kb]   (695 Downloads)    
Subject: Adults Hematology & Oncology
Received: 2023/02/19 | Accepted: 2023/03/17 | Published: 2023/03/30
References
1. Mehrpouri M, Pourbagheri-Sigaroodi A, Bashash D. The contributory roles of histone deacetylases (HDACs) in hematopoiesis regulation and possibilities for pharmacologic interventions in hematologic malignancies. International Immunopharmacology. 2021;100:108114. [DOI:10.1016/j.intimp.2021.108114]
2. Adam MNM, Adam MNM, Idris AAA, Ali ASM, Khalid IO. A rare diagnostic case of angioimmunoblastic T-cell lymphoma: . Science Progress and Research (SPR). 2022;2(1):414-8. [DOI:10.52152/spr/2022.165]
3. Shin WY, Bang HI, Kim J-A, Kim J, Park R. Angioimmunoblastic T-Cell Lymphoma with Polyclonal Proliferation of Plasma Cells: A Cautionary Note for Flow Cytometry Interpretations. Korean Journal of Clinical Laboratory Science. 2022;54(1):68-72. [DOI:10.15324/kjcls.2022.54.1.68]
4. Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBdO, Berti E, Bhagat G, Borges AM, Boyer D, Calaminici M. The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia. 2022;36(7):1720-48. [DOI:10.1038/s41375-022-01620-2]
5. Jain G, Kumar C, Malhotra A, Mallick SR, Bakhshi S, Chopra A. Peripheral blood involvement in angioimmunoblastic T-cell lymphoma: A case report and review of the literature. American Journal of Blood Research. 2020;10(5):257.
6. Xie Y, Jaffe ES. How I diagnose angioimmunoblastic T-cell lymphoma. American Journal of Clinical Pathology. 2021;156(1):1-14. [DOI:10.1093/ajcp/aqab090]
7. Džeko Škugor N, Perić Z, Vrhovac R, Radić-Krišto D, Kardum-Skelin I, Jakšić B. Diffuse Large B-cell Lymphoma in Patient after Treatment of angioimmunoblastic T-cell Lymphoma. Collegium antropologicum. 2010;34(1):241-5.
8. Ferran M, Gallardo F, Baena V, Ferrer A, Florensa L, Pujol RM. The 'deck chair sign'in specific cutaneous involvement by angioimmunoblastic T cell lymphoma. Dermatology. 2006;213(1):50-2. [DOI:10.1159/000092841]
9. Hori H, Tanaka Y, Nakayama R, Nohgawa M. CD56-positive Angioimmunoblastic T-cell Lymphoma Complicated by Chylothorax. Internal Medicine. 2022;61(5):729-33. [DOI:10.2169/internalmedicine.7783-21]
10. Swarup S, Kopel J, Thein KZ, Tarafdar K, Swarup K, Thirumala S, Quick DP. Sequential Complications of Hypercalcemia, Necrotizing Granulomatous Vasculitis, and Aplastic Anemia Occurring in One Patient with Angioimmunoblastic T-cell Lymphoma. The American journal of the medical sciences. 2021;361(3):375-82. [DOI:10.1016/j.amjms.2020.09.003]
11. Wawrzycki B, Prystupa A, Szumiło J, Panasiuk L, Krasowska D. Fever, rash, and eosinophilia-early signs of angioimmunoblastic T-cell lymphoma. Annals of Agricultural and Environmental Medicine. 2021;28(3):525. [DOI:10.26444/aaem/140594]
12. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann T, Mulrow CD, Shamseer L, Moher D. Mapping of reporting guidance for systematic reviews and meta-analyses generated a comprehensive item bank for future reporting guidelines. Journal of clinical epidemiology. 2020;118:60-8. [DOI:10.1016/j.jclinepi.2019.11.010]
13. Mohammed Saleh MF, Kotb A, Abdallah GE, Muhsen IN, El Fakih R, Aljurf M. Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma. Current Oncology. 2021;28(6):5480-98. [DOI:10.3390/curroncol28060456]
14. McBride AB, Porcu P. The rise of a new "great teacher". Blood, The Journal of the American Society of Hematology. 2021;138(3):205-6. [DOI:10.1182/blood.2021011754]
15. Nguyen PN, Tran NT, Nguyen TP, Ngo TN, Van Lai D, Deel CD, Hassell LA, Vuong HG. Clinicopathological Implications of RHOA Mutations in Angioimmunoblastic T-Cell Lymphoma: A Meta-analysis: RHOA mutations in AITL. Clinical Lymphoma Myeloma and Leukemia. 2021;21(7):431-8. [DOI:10.1016/j.clml.2021.03.002]
16. Horesh N, Horowitz NA. Does gender matter in non-Hodgkin lymphoma? Differences in epidemiology, clinical behavior, and therapy. Rambam Maimonides medical journal. 2014;5(4). [DOI:10.5041/RMMJ.10172]
17. Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harbor perspectives in biology. 2014;6(10):a016295. [DOI:10.1101/cshperspect.a016295]
18. Chiba S, Sakata-Yanagimoto M. Advances in understanding of angioimmunoblastic T-cell lymphoma. Leukemia. 2020;34(10):2592-606. [DOI:10.1038/s41375-020-0990-y]
19. Lunning MA, Vose JM. Angioimmunoblastic T-cell lymphoma: the many-faced lymphoma. Blood, The Journal of the American Society of Hematology. 2017;129(9):1095-102. [DOI:10.1182/blood-2016-09-692541]
20. Jeong J, Yu JE, Choi YD, Kim SK, Yoon W, Koh Y-I. Differentiation of angioimmunoblastic T-cell lymphoma from DRESS syndrome. The Journal of Allergy and Clinical Immunology: In Practice. 2019;7(5):1684-6. e1. [DOI:10.1016/j.jaip.2018.11.048]
21. Burns EA, Anand K, Chung B, Shah S, Randhawa JK, Pingali SR. The development of T-cell malignancies in patients with pre-existing myeloproliferative neoplasms: a report of three cases. ecancermedicalscience. 2020;14. [DOI:10.3332/ecancer.2020.1011]
22. Kanderi T, Goel S, Shrimanker I, Nookala VK, Singh P. Angioimmunoblastic T-cell Lymphoma: An Unusual Case in an Octogenarian. Cureus. 2020;12(2). [DOI:10.7759/cureus.6956]
23. Kuroda K, Tambe A, Iftikhar R, Nat AS, Basnet A. A Case of Angioimmunoblastic T-cell Lymphoma That Mimics As Autoimmune Diseases and Infections. Cureus. 2021;13(7). [DOI:10.7759/cureus.16439]
24. Genovesi-Ebert A, Lombardi M, Capochiani E, Simi U, Savoia MT, Baldini U, Digiorgio A, Carluccio M, Di Santo D, Galli M. Heart involvement in T cell lymphoma through hypereosinophilic syndrome: a common complication of a rare condition. Journal of Cardiovascular Magnetic Resonance. 2005;7(2):495-9. [DOI:10.1081/JCMR-200053524]
25. Yabe M, Dogan A, Horwitz SM, Moskowitz AJ. Angioimmunoblastic T-cell lymphoma. T-Cell and NK-Cell Lymphomas. 2019:99-126. [DOI:10.1007/978-3-319-99716-2_5]
26. Lee WJ, Won KH, Choi JW, Won CH, Chang SE, Choi JH, Lee MW. Cutaneous angioimmunoblastic T-cell lymphoma: Epstein-Barr virus positivity and its effects on clinicopathologic features. Journal of the American Academy of Dermatology. 2019;81(4):989-97. [DOI:10.1016/j.jaad.2018.08.053]
27. Ahsanuddin AN, Brynes RK, Li S. Peripheral blood polyclonal plasmacytosis mimicking plasma cell leukemia in patients with angioimmunoblastic T-cell lymphoma: report of 3 cases and review of the literature. International Journal Of Clinical and Experimental Pathology. 2011;4(4):416.
28. Mourad N, Mounier N, Brière J, Raffoux E, Delmer A, Feller A, Meijer CJ, Emile J-F, Bouabdallah R, Bosly A. Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials. Blood, The Journal of the American Society of Hematology. 2008;111(9):4463-70. [DOI:10.1182/blood-2007-08-105759]
29. Gabali A. Flow cytometry, molecular analysis, and other special techniques (in Serous Fluid Cytopathology). CytoJournal. 2022;19. [DOI:10.25259/CMAS_02_13_2021]
30. Loghavi S, Wang SA, Jeffrey Medeiros L, Jorgensen JL, Li X, Xu-Monette ZY, Miranda RN, Young KH. Immunophenotypic and diagnostic characterization of angioimmunoblastic T-cell lymphoma by advanced flow cytometric technology. Leukemia & lymphoma. 2016;57(12):2804-12. [DOI:10.3109/10428194.2016.1170827]
31. Satoh T, Kayano H, Takahashi N, Tsukasaki K, Yasuda M. Diagnostic utility of the aberrant immunohistochemical expression of CD3 molecules for peripheral T-cell lymphomas. Annals of Diagnostic Pathology. 2022;60:152013. [DOI:10.1016/j.anndiagpath.2022.152013]
32. Baseggio L, Berger F, Morel D, Delfau-Larue M, Goedert G, Salles G, Magaud J, Felman P. Identification of circulating CD10 positive T cells in angioimmunoblastic T-cell lymphoma. Leukemia. 2006;20(2):296-303. [DOI:10.1038/sj.leu.2404013]
33. Patel BK, Basu D, Kar R, Dubashi B. Immunophenotyping of Nodal Peripheral T-cell Lymphomas and its Association with Epstein-Barr Virus. Iranian Journal of Blood and Cancer. 2019;11(3):101-8.
34. Chen N, Amber S. Eosinophilia and Cutaneous Involvement in Angioimmunoblastic T-Cell Lymphoma. Journal of Allergy and Clinical Immunology. 2016;137(2, Supplement):AB169-AB70. [DOI:10.1016/j.jaci.2015.12.689]
35. Hapgood G, Mottok A, Slack GW, Gascoyne RD, Steidl C, Savage KJ, Weng AP. Flow Cytometric Characterization of 129 Cases of Peripheral T Cell Lymphoma Not Otherwise Specified (PTCL NOS) and Angioimmunoblastic T Cell Lymphoma (AITL). Blood. 2015;126(23):2667. [DOI:10.1182/blood.V126.23.2667.2667]
36. Satou A, Takahara T, Tsuzuki T. Pathological and Molecular Features of Nodal Peripheral T-Cell Lymphomas. Diagnostics. 2022;12(8):2001. [DOI:10.3390/diagnostics12082001]
37. Bahmani F, Azadpour S, Pourbagheri-Sigaroodi A, Bashash D. Plant-derived natural compounds as promising anticancer agents in hematological malignancies. Iranian Journal of Blood and Cancer. 2022;14(3):57-70.
38. SAHU S, DONGRE N. A Review on Analytical Method Development and Validation of Cyclophosphamide.
39. Tacar O, Sriamornsak P, Dass CR. Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. Journal of pharmacy and pharmacology. 2013;65(2):157-70. [DOI:10.1111/j.2042-7158.2012.01567.x]
40. Avendano C, Menendez JC. Anticancer drugs targeting tubulin and Microtubules. Medicinal Chemistry of Anticancer Drugs Elsevier, Boulevard. 2015:359-87. [DOI:10.1016/B978-0-444-62649-3.00009-0]
41. Puckett Y, Gabbar A, Bokhari AA. Prednisone. 2018.
42. Moskowitz AJ. Practical treatment approach for angioimmunoblastic T-cell lymphoma. Journal of oncology practice. 2019;15(3):137-43. [DOI:10.1200/JOP.18.00511]
43. Yoon SE, Cho J, Kim YJ, Kim SJ, Kim WS. Real-World Efficacy of 5-Azacytidine as Salvage Chemotherapy for Angioimmunoblastic T-cell Lymphoma. Clinical Lymphoma Myeloma and Leukemia. 2022;22(11):e972-e80. [DOI:10.1016/j.clml.2022.07.009]
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 All Rights Reserved | Iranian Journal of Blood and Cancer

Designed & Developed by : Yektaweb