Wnt7b as a novel candidate in silico analysis of angiogenesis-related expressed genes in non-small cell lung cancer patients

Soltanpor Dehkordi, Amin; Sayahinouri, Maryam; Hosseininia, Haniyeh Sadat; Kazempour, Alireza; Mehtar Araghinia, Romina; Saadati Partan, Arman; Ebrahimi Sadrabadi, Amin; Jalili, Arsalan

Volume 15, Issue 4 (September 2023 2023) Iranian Journal of Blood and Cancer 2023, 15(4): 236-252 | Back to browse issues page

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Soltanpor Dehkordi A, Sayahinouri M, Hosseininia H S, Kazempour A, Mehtar Araghinia R, Saadati Partan A, et al . Wnt7b as a novel candidate in silico analysis of angiogenesis-related expressed genes in non-small cell lung cancer patients. Iranian Journal of Blood and Cancer 2023; 15 (4) :236-252
URL: http://ijbc.ir/article-1-1406-en.html

Wnt7b as a novel candidate in silico analysis of angiogenesis-related expressed genes in non-small cell lung cancer patients

Amin Soltanpor Dehkordi¹, Maryam Sayahinouri², Haniyeh Sadat Hosseininia³, Alireza Kazempour⁴, Romina Mehtar Araghinia⁵, Arman Saadati Partan⁶, Amin Ebrahimi Sadrabadi⁷, Arsalan Jalili ^*⁸

1- Department of Mycology and Parasitology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2- Department of Immunology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
3- Department of Cellular and Molecular Biology, Faculty of Advanced Medical Science, Islamic Azad University of Medical Sciences, Tehran, Iran
4- Department of Microbiology, Faculty of Science, Lahijan Branch, Islamic Azad University, Gilan, Iran
5- Department of Biology, Faculty of Science, Tonekabon Branch, Islamic Azad University, Mazandaran, Iran
6- Department of Microbiology, Islamic Azad University, Karaj Branch, Karaj, Iran
7- Department of Stem Cells and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
8- Department of Stem Cells and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran , Jalili.arsalan@yahoo.com

Abstract: (94 Views)

According to the latest WHO report, lung cancer ranks among the top cancer-associated mortalities. Moreover, it has been related to a high rate of metastasis, which indicates the importance of angiogenesis. Histologically, lung cancer is divided into NSCLC and SCLC, with NSCLC being the most common. Angiogenesis is essential for tumor development. Additionally, immune cells, soluble factors, and ECM play a crucial role in their formation. this study reviews the angiogenesis formation factors in previous studies as well as analyzes in silico angiogenesis-related genes in NSCLCs. It is reported that EPhB2, PIK3R2, HSPB1and Wnt7b were the most upregulated angiogenesis genes. Among them, Wnt7b is the most prevalent in NSCLC subtypes. Moreover, a decrease of 50% in overall survival in both low and high Wnt7b transcripts per million was observed. First, three high-throughput GEO data sets with 18 lung cancer and normal samples were adopted to achieve the study purpose. Then, the up-and-down-regulated genes with p-value <0.05 were isolated. Next, the genes were taken to the Enrichr and the KEGG databases. Lastly, our in-silico analysis confirmed the gene expression connection between angiogenesis and lung cancer invasion.

Keywords: Wnt7b, EPhB2, Angiogenesis, Lung cancer, In silico, Bioinformatics

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: Review Article | Subject: Adults Hematology & Oncology
Received: 2023/07/10 | Accepted: 2023/08/20 | Published: 2023/09/17

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