Volume 15, Issue 4 (September 2023 2023)                   Iranian Journal of Blood and Cancer 2023, 15(4): 272-292 | Back to browse issues page

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Wajahat S. Role of microorganisms in the developmental, prognostic, and therapeutics of gastric cancer. Iranian Journal of Blood and Cancer 2023; 15 (4) :272-292
URL: http://ijbc.ir/article-1-1437-en.html
Department of Biosciences, Mohammad Ali Jinnah University, Karachi, Pakistan , s.sadaf.wajahat@gmail.com
Abstract:   (496 Views)
Gastric cancer (GC) is the most frequent destructive polyp allied to the GIT. It is reported as the foremost oncological complication with a prevalence ranks fifth and mortality ranks fourth worldwide with a survival rate of <25% in five years. In GC, men were observed as 2-3 times more susceptible to incidence and mortality than women. The GC patients experienced a burden of symptoms with multiple co-occurring symptoms including pain, weight loss, depression, fatigue, dysphagia, nausea, vomiting, etc. The risk factors of GC include infection of H. pylori, smoking, obesity, hereditary, high salt, radiation, and the frequent use of medications, etc. The role of genes, long-coding RNAs, metabolomics, machine learning, plant extracts, and nanoparticles has been studied for the progression, diagnosis, and treatment of GC. Due to the progressive stage diagnosis and lack of competent therapy, an imperative requirement is the identification of sensitive and accurate biomarkers towards the initial prognosis and the development of innovative therapeutic approaches. Microorganisms execute a momentous role in human health by contributing to immune system development and accomplishing an extensive range of metabolic functions. The disturbance in the stability of the microbes may stimulate various diseases including cancer. This review focuses on the role of microorganisms in the development, prognosis, and therapy of GC.
Full-Text [PDF 7319 kb]   (142 Downloads)    
: Review Article | Subject: Gastroentrology
Received: 2023/07/6 | Accepted: 2023/09/18 | Published: 2023/09/27

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