Volume 16, Issue 1 (March 2024 2024)                   Iranian Journal of Blood and Cancer 2024, 16(1): 1-20 | Back to browse issues page


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Sohani M, Rastgar A, Kheyrandish S. Harnessing the Power of MAGE Proteins in Cancer Immunotherapy for Multiple Myeloma. Iranian Journal of Blood and Cancer 2024; 16 (1) :1-20
URL: http://ijbc.ir/article-1-1442-en.html
1- Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Department of Hematology and Blood Banking, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3- Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , 7masterstar@gmail.com
Abstract:   (726 Views)

This document is a comprehensive review that focuses on the role of melanoma-associated antigen genes (MAGE) family proteins in cancer, with a specific emphasis on their involvement in multiple myeloma (MM). The expression patterns of MAGE proteins in different tissues and their association with critical cellular processes such as cell cycle progression, apoptosis, and gene expression regulation were discussed. The document also highlighted the potential utility of MAGE proteins in cancer immunotherapy, including their use in prognosis and the development of MAGE-based cancer vaccines. In cancer vaccine therapy antigen selection is a crucial step, so by focusing on the vast potency of MAGE, we tried to mention it as a potent antigen for therapy of MM by reviewing the current studies. However, we acknowledged the need for further research and extensive clinical trials to evaluate the effectiveness, safety, and potency of MAGE antigens.

Full-Text [PDF 843 kb]   (152 Downloads)    
: Review Article | Subject: Adults Hematology & Oncology
Received: 2023/10/10 | Accepted: 2023/12/7 | Published: 2024/03/25

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