BCR-ABL positive T cell Acute Lymphoblastic Leukemia (T-ALL): Exploring A Rare Case with A Comprehensive Review

Kheyrandish, Setare; Shadani, Shiva; Eghbali, Aziz; Poopak, Behzad; Bashash, Davood

doi:10.61186/ijbc.16.2.1

Volume 16, Issue 2 (June 2024 2024) Iranian Journal of Blood and Cancer 2024, 16(2): 1-6 | Back to browse issues page

‎ 10.61186/ijbc.16.2.1

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Kheyrandish S, Shadani S, Eghbali A, Poopak B, Bashash D. BCR-ABL positive T cell Acute Lymphoblastic Leukemia (T-ALL): Exploring A Rare Case with A Comprehensive Review. Iranian Journal of Blood and Cancer 2024; 16 (2) :1-6
URL: http://ijbc.ir/article-1-1552-en.html

BCR-ABL positive T cell Acute Lymphoblastic Leukemia (T-ALL): Exploring A Rare Case with A Comprehensive Review

Setare Kheyrandish¹

, Shiva Shadani²

, Aziz Eghbali²

, Behzad Poopak³

, Davood Bashash ^*

⁴

1- Student Research Committee, Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Clinical Research Development Center of Aliasghar Hospital, Iran University of Medical Sciences, Tehran, Iran.
3- Department Of Medical Laboratory Sciences, Faculty of Paramedical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
4- Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , david_5980@yahoo.com

Abstract: (578 Views)

CD4⁺/CD8⁺ double-positive (DP) thymocytes are normal cells within the thymus. However, the presence of mature DP T cells is indicative of cancer and abnormality in peripheral blood. Philadelphia⁺ (Ph⁺) T-ALL is extremely rare, but it holds significant therapeutic and prognostic implications. The incidence and outcomes of BCR-ABL⁺ T-ALL remain uncertain, and distinguishing it from T-cell lymphoblastic crises of CML can be challenging. The current document discussed a rare case of CD4⁺/CD8⁺ BCR-ABL⁺ T-ALL in an 11-year-old Iranian male, detailing his medical conditions, laboratory findings, and treatment. The patient presented with enlarged lymph nodes, splenomegaly, anemia, leukocytosis, and severe thrombocytopenia. The blood smear was nearly filled with irregular/convoluted and cleaved nuclear blasts with fine chromatin. The patient received imatinib with induction chemotherapy. After two months, the patient achieved complete remission with undetectable Minimal/Measurable Residual Disease (MRD). By detailing the patient's characteristics and the required tests, the manuscript contributes to a deeper understanding of this complex disease subtype. Furthermore, by examining and comparing the current case with other available cases, the study lays the groundwork for better characterizing the disease and developing more effective therapeutic strategies.

Keywords: P-190 BCR-ABL, Philadelphia, CD4+/CD8+ double-positive T-ALL, Malignancy

Full-Text [PDF 677 kb] (308 Downloads)

: Case report | Subject: Pediatric Hematology & Oncology
Received: 2024/05/1 | Accepted: 2024/06/22 | Published: 2024/06/30

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