Volume 16, Issue 3 (September 2024 2024)                   Iranian Journal of Blood and Cancer 2024, 16(3): 14-22 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Adib Bakhsh R, Saleh Dairi K, Hamid Alabdali M, Mohammed Aljuhani S, Khaled Altaib R, Ahmed Hasaballah M. A Patient with Splenomegaly and Systemic Lupus Erythematosus Diagnosed with Lymphoma: A Case Report and Systematic Literature Review. Iranian Journal of Blood and Cancer 2024; 16 (3) :14-22
URL: http://ijbc.ir/article-1-1580-en.html
A Patient with Splenomegaly and Systemic Lupus Erythematosus Diagnosed with Lymphoma: A Case Report and Systematic Literature Review
Raja Adib Bakhsh * 1, Khaled Saleh Dairi2 , Mohammad Hamid Alabdali2 , Sameer Mohammed Aljuhani2 , Rawan Khaled Altaib2 , Mohammed Ahmed Hasaballah2
1- King Faisal Hospital, Internal Medicine Department, 4588, Prince Majed ibn Abd Al Aziz, 7451, Al Maabdah, Makkah 24236, Saudi Arabia. , rajaa_bakhsh09@outlook.com
2- King Faisal Hospital, Internal Medicine Department, 4588, Prince Majed ibn Abd Al Aziz, 7451, Al Maabdah, Makkah 24236, Saudi Arabia.
Abstract:   (184 Views)
Systemic Lupus Erythematosus (SLE) is one of these conditions that presents difficult hurdles since it is a multi-systemic autoimmune condition with a wide range of implications, including an increased risk of cancer among affected people. According to recent evidence, it has been revealed that the lymphoma rate in patients with SLE can be 4 to 7 times higher than that of the general population. This increased risk is to be emphasized through stringent and attentive screening and management as the mechanism of this risk is still under research. Therefore, this section discusses a case study and literature regarding SLE and lymphoma better to comprehend the intricate correlation between the two conditions. Here, we present the case of a 53-year-old male who was just diagnosed with SLE and also suffering from abdominal pain and distention, in which the diagnosis of lymphoma is made via serial investigations. This case, therefore, gives us a lesson on the fact that Lymphoma should be considered as one of the differential diagnoses in SLE patients presenting with abdominal complaints. With the ever-changing knowledge about the basic mechanisms of SLE and appropriate screening techniques, our attention to cancer risk in SLE patients should be increased to achieve better clinical outcomes.
Keywords: Systemic Lupus Erythematosus, Lymphoma, Vasculitis, Autoimmune, Abdominal Manifestation
Full-Text [PDF 676 kb]   (158 Downloads)    
: Review Article | Subject: Adults Hematology & Oncology
Received: 2024/07/2 | Accepted: 2024/09/17 | Published: 2024/09/30
References
1. Gergianaki, I. and G. Bertsias, Systemic lupus erythematosus in primary care: an update and practical messages for the general practitioner. Frontiers in medicine, 2018. 5: p. 161. [DOI:10.3389/fmed.2018.00161]
2. Pavli, P., et al., Acute abdominal situations as presenting or flaring manifestations of systemic lupus erythematosus: a case series. Mediterranean Journal of Rheumatology, 2022. 33(3): p. 339. [DOI:10.31138/mjr.33.3.339]
3. Mounir, B., et al., Acute intestinal obstruction in systemic lupus Erythematosus: Case report and review of the literature. Global Journal of Rare Diseases, 2023. 8(1): p. 001-005. [DOI:10.17352/2640-7876.000035]
4. Chen, L., et al., Clinical features of lupus enteritis: a single-center retrospective study. Orphanet journal of rare diseases, 2021. 16: p. 1-8. [DOI:10.1186/s13023-021-02044-4]
5. Yulistiawati, F., A case report of a woman with SLE and lupus enteritis as the first manifestation of active systemic lupus erythematosus. Bali Medical Journal, 2023. 12(2): p. 1321-1237. [DOI:10.15562/bmj.v12i2.4291]
6. Frittoli, R.B., et al., Gastrointestinal involvement in systemic lupus erythematosus: A systematic review. Journal of translational autoimmunity, 2021. 4: p. 100106. [DOI:10.1016/j.jtauto.2021.100106]
7. Paramaiswari, A., A. Kusumawati, and D.B. Nugroho, Severe Abdominal Pain and Multi-Organ Involvement in a Young Woman With Systemic Lupus Erythematosus. Journal of Medical Cases, 2023. 14(6): p. 196. [DOI:10.14740/jmc4065]
8. Barile-Fabris, L., M. Hernández-Cabrera, and J. Barragan-Garfias, Vasculitis in systemic lupus erythematosus. Current rheumatology reports, 2014. 16: p. 1-6. [DOI:10.1007/s11926-014-0440-9]
9. Miyagawa, F., et al., A case of systemic lupus erythematosus with cutaneous leukocytoclastic vasculitis mimicking bullous SLE. Case Reports in Dermatology, 2022. 13(3): p. 464-469. [DOI:10.1159/000519022]
10. Kallas, R., D. Goldman, and M.A. Petri, Cutaneous vasculitis in SLE. Lupus Science & Medicine, 2020. 7(1): p. e000411. [DOI:10.1136/lupus-2020-000411]
11. Gheita, T., et al., Cutaneous vasculitis in systemic lupus erythematosus patients: potential key players and implications. Lupus, 2018. 27(5): p. 738-743. [DOI:10.1177/0961203317739134]
12. Klein, A., A. Polliack, and A. Gafter-Gvili, Systemic lupus erythematosus and lymphoma: Incidence, pathogenesis and biology. Leukemia research, 2018. 75: p. 45-49. [DOI:10.1016/j.leukres.2018.11.004]
13. Ladouceur, A., et al., Cancer and systemic lupus erythematosus. Rheumatic Disease Clinics, 2020. 46(3): p. 533-550. [DOI:10.1016/j.rdc.2020.05.005]
14. Martín-López, M., et al., Clinical characteristics and risk factors associated with lymphoma in patients with systemic lupus erythematosus: a nationwide cohort study. Rheumatology, 2023. 62(1): p. 217-224. [DOI:10.1093/rheumatology/keac258]
15. Shaharir, S. and C. Gordon, Constitutional symptoms and fatigue in systemic lupus erythematosus, in Systemic Lupus Erythematosus. 2016, Elsevier. p. 317-324. [DOI:10.1016/B978-0-12-801917-7.00037-1]
16. Iwamuro, M., et al., Intestinal Diffuse Large B-Cell Lymphoma in a Patient with Systemic Lupus Erythematosus. Case Reports in Gastrointestinal Medicine, 2020. 2020. [DOI:10.1155/2020/7947540]
17. Qattan, M.Y., The Incidence Rate of Non-Hodgkin's Lymphoma in Saudi Arabia: An Observational Descriptive Population Based Epidemiological Study from the Saudi Cancer Registry (2006-2016). Open Access Macedonian Journal of Medical Sciences, 2023. 11(B): p. 445-452. [DOI:10.3889/oamjms.2023.11566]
18. Song, L., et al., The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis. Arthritis research & therapy, 2018. 20: p. 1-13. [DOI:10.1186/s13075-018-1760-3]
19. Saadoun, D., et al., Expansion of autoreactive unresponsive CD21−/low B cells in Sjögren's syndrome-associated lymphoproliferation. Arthritis & Rheumatism, 2013. 65(4): p. 1085-1096. [DOI:10.1002/art.37828]
20. Boddu, P., et al., SLE and non-Hodgkin's lymphoma: a case series and review of the literature. Case Reports in Rheumatology, 2017. 2017. [DOI:10.1155/2017/1658473]
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 All Rights Reserved | Iranian Journal of Blood and Cancer

Designed & Developed by : Yektaweb