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Volume 17, Issue 4 (December-2025 2025)
Iranian Journal of Blood and Cancer 2025, 17(4): 82-103 |
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Anjali P, Ushakiran P, Haria J. Unravelling the Role of IL-6, TNF-alpha and CRP in Pathogenesis of Coronary Artery Disease: A Systematic Review. Iranian Journal of Blood and Cancer 2025; 17 (4) :82-103
URL: http://ijbc.ir/article-1-1769-en.html
URL: http://ijbc.ir/article-1-1769-en.html
1- Department of Biochemistry, Teerthanker Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University, Moradabad, UP, India. , priyaanjali01116@gmail.com
2- Department of Biochemistry, Teerthanker Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University Moradabad, UP, India.
3- Department of Medicine, Teerthanker Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University Moradabad, UP, India.
2- Department of Biochemistry, Teerthanker Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University Moradabad, UP, India.
3- Department of Medicine, Teerthanker Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University Moradabad, UP, India.
Abstract: (19 Views)
Background: India has high incidence of cardiovascular disease and coronary artery disease (CAD). Coronary artery disease is attaining epidemic proportions in India. Higher levels of C-reactive protein were connected to an augmented risk of coronary heart disease (CHD). TNF-alpha & IL-6 contribute in the pathogenesis of CHD and their levels are closely linked with the extent of coronary heart disease.
Aim and objectives: This objective of this review is to analyze the status of inflammatory markers and to establish their relation with the extent of CAD.
Methodology: The literature search for this review was done through databases incorporated are PubMed, Web of sciences, Scopus, Medline, Research Gate and Google scholar. The keywords used were “coronary artery disease”, “inflammatory markers,” and “cytokines in inflammation”. The Preferred Reporting Items for Systematic Research and Meta-Analysis (PRISMA) were used to build this review article.
Results: There were 1860 articles found which were relevant to the aim of our review, out of which only 57 fulfilled the inclusion criteria. A substantial variability across the studies was found. To figure out its correlation with inflammatory processes, these studies employed a variety of inflammatory markers. Most studies found a high level of inflammatory markers such as IL-6, TNF-alpha, and CRP in patients with coronary artery disease and cardiovascular disease.
Conclusion: Data from the literature searched highlighted a significant association between inflammatory markers and CAD.
Aim and objectives: This objective of this review is to analyze the status of inflammatory markers and to establish their relation with the extent of CAD.
Methodology: The literature search for this review was done through databases incorporated are PubMed, Web of sciences, Scopus, Medline, Research Gate and Google scholar. The keywords used were “coronary artery disease”, “inflammatory markers,” and “cytokines in inflammation”. The Preferred Reporting Items for Systematic Research and Meta-Analysis (PRISMA) were used to build this review article.
Results: There were 1860 articles found which were relevant to the aim of our review, out of which only 57 fulfilled the inclusion criteria. A substantial variability across the studies was found. To figure out its correlation with inflammatory processes, these studies employed a variety of inflammatory markers. Most studies found a high level of inflammatory markers such as IL-6, TNF-alpha, and CRP in patients with coronary artery disease and cardiovascular disease.
Conclusion: Data from the literature searched highlighted a significant association between inflammatory markers and CAD.
: Review Article |
Subject:
Immunology
Received: 2025/10/12 | Accepted: 2025/12/11 | Published: 2025/12/30
Received: 2025/10/12 | Accepted: 2025/12/11 | Published: 2025/12/30
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