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IJBC 2009, 1(2): 49-54 Back to browse issues page
Studies of Human HbAA Erythrocyte Osmotic Fragility Index of Non-Malarious Blood in the Presence of Five Anti-malarial Drugs
Paul Chikezie *, Augustine Uwakwe, Comfort Monago
Abstract:   (30688 Views)

Background: The capacity of human HbAA erythrocytes of non-malarious blood to withstand osmotic stress in the presence of five antimalarial drugs, Chloroquine phosphate, Quinine, FansidarTM, CoartemTM and HalfanTM was studied in vitro.

Materials and Methods: Aqueous solutions of four increasing concentrations of the drugs used in this investigation were in the order: 0.2%, 0.4%, 0.6% and 0.8% (w/v). Spectrophotometric method was employed to ascertain the osmotic fragility index of the erythrocytes. The mean corpuscular fragility (MCF) index (X+S.D) of the control sample was 0.351+0.06 g/100ml. The MCF values of the control and test samples were statistically compared (p value = 0.05).

Results: At the drug concentration of 0.8g, MCF values (g) of 0.401±0.005, 0.391±0.003, 0.364±0.02, 0.344±0.02 and 0.338±0.04 were obtained for halfan, coartem, quinine, chloroquine phosphate and fansidar, respectively.

Conclusion: An overview of the results showed that in a concentration dependent manner, Choroquine phosphate and FansidarTM exhibited a diminishing capacity to stabilize red blood cell membrane while HalfanTM CoartemTM and Quinine elicited an increasing propensity to disrupt erythrocyte membrane integrity.

Keywords: osmotic fragility, quinine, fansiderTM, chlonquine phosphate, coartemTM, halfanTM
Full-Text [PDF 223 kb]   (7530 Downloads)    
: Research | Subject: Pediatric Hematology & Oncology
Received: 2011/01/26 | Published: 2009/12/15
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Chikezie P, Uwakwe A, Monago C. Studies of Human HbAA Erythrocyte Osmotic Fragility Index of Non-Malarious Blood in the Presence of Five Anti-malarial Drugs. IJBC. 2009; 1 (2) :49-54
URL: http://ijbc.ir/article-1-18-en.html

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Volume 1, Issue 2 (Winter 2009) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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