Volume 12, Issue 4 ( December 2020 2020)                   Iranian Journal of Blood and Cancer 2020, 12(4): 111-120 | Back to browse issues page

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Saeidnia M, Nam Avar Jahromi F, Vaziee E, Dehghani H, Mahmoodzade A, Tamaddon G. Thrombotic Thrombocytopenic Purpura: Diagnosis and Treatment. Iranian Journal of Blood and Cancer 2020; 12 (4) :111-120
URL: http://ijbc.ir/article-1-1011-en.html
Thrombotic Thrombocytopenic Purpura: Diagnosis and Treatment
Mohammadreza Saeidnia1 , Faride Nam Avar Jahromi1 , Elnaz Vaziee1 , Hossein Dehghani1 , Amir Mahmoodzade2 , Gholamhossein Tamaddon *3
1- Department of Hematology, School of Paramedical, Shiraz University of Medical Sciences, Shiraz, Iran
2- Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran , tamaddon.g@gmail.com
Abstract:   (3269 Views)
Thrombotic Thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathic disease, associated with thrombocytopenia and hemolytic anemia. It is caused by an enzymatic dysfunction responsible in cleavage of blood clotting factors. In this study we have tried to review the available approaches in diagnoses of the disease as well as treatment strategies. Based on the what the current review has provided, treatment policy depends on accurate diagnosis, it seems that developing a diagnostic and treatment guide for this disease is currently essential. Also, it’s necessary to study genetic types of TTP with more details because, hopefully, new techniques of gene therapy open a window to more stable treatments.
Keywords: Thrombotic thrombocytopenic purpura, Diagnosis, Gene therapy
Full-Text [PDF 533 kb]   (1746 Downloads)    
: Review Article | Subject: Adults Hematology & Oncology
Received: 2020/05/27 | Accepted: 2020/10/7 | Published: 2020/12/31
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