Setare Kheyrandish and colleagues reported an unusual case of CD4+/CD8+ BCR-ABL+ T-ALL in an 11-year-old male from Iran, providing a comprehensive overview of his medical history, laboratory results, and treatment regimen. The patient exhibited symptoms such as swollen lymph nodes, splenomegaly, anemia, leukocytosis, and significant thrombocytopenia. The blood smear analysis revealed a predominance of irregular, convoluted, and cleaved nuclear blasts characterized by fine chromatin. The treatment protocol included imatinib in conjunction with induction chemotherapy. Following a two-month treatment period, the patient attained complete remission, with Minimal/Measurable Residual Disease (MRD) levels being undetectable. By outlining the patient's clinical features and necessary diagnostic evaluations, this manuscript enhances the understanding of this intricate disease subtype. Additionally, through the examination and comparison of this case with existing literature, the research establishes a foundation for improved characterization of the disease and the formulation of more effective treatment approaches. The full-text of their article is available for download here.
Guideline for Diagnosis and Treatment of Osteoporosis in Transfusion-Dependent Thalassemia Patients
In recent years, the health-related quality of life and management of patients suffering from thalassemia have seen considerable advancements, primarily due to the implementation of standard treatments and the availability of safe blood transfusions, complemented by effective chelation therapy aimed at mitigating iron overload. Transfusion-dependent thalassemia is linked to various skeletal deformities, notably osteoporosis, which poses a significant morbidity risk for these individuals. Osteoporosis is defined by diminished bone mass and an elevated likelihood of fractures, especially in the lumbar region and among patients experiencing extramedullary hematopoiesis. In light of the significant occurrence of thalassemia-related osteoporosis in Iran and the associated challenges it poses to both individuals and the healthcare system, Mojtaba Malek et al. established a national protocol aimed at preventing the progression of this condition, emphasizing the importance of early diagnosis and prompt treatment. The full-text of their article is available for download here.
This document is a comprehensive review that focuses on the role of melanoma-associated antigen genes (MAGE) family proteins in cancer, with a specific emphasis on their involvement in multiple myeloma (MM). The expression patterns of MAGE proteins in different tissues and their association with critical cellular processes such as cell cycle progression, apoptosis, and gene expression regulation were discussed. The document also highlighted the potential utility of MAGE proteins in cancer immunotherapy, including their use in prognosis and the development of MAGE-based cancer vaccines. The full-text of the article is available for download here,
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- BCR-ABL positive T cell Acute Lymphoblastic Leukemia (T-ALL): Exploring A Rare Case with A Comprehensive Review
Setare Kheyrandish, Shiva Shadani, Aziz Eghbali, Behzad Poopak, Davood Bashash * - Categorized Serum miRNAs as Potential Biomarkers for Predicting the Progression and Prognosis of Colorectal Cancer
Meral Merve Oğuz, Ehteram Khademi Siahestalkhi *, Arzu Yaren, Aydin Demiray, Atike Gökçen Demiray - Evaluating Adverse Events in COVID-19 Recovered Convalescent Plasma Donors: A Comprehensive Analysis
Shalini Bahadur, Bhumika Gupta, Shalini Shukla, Paridhi - *, Shivani Kalhan, Madhuvan Gupta - High Variability in HLA-DRB1*03, a Predisposing Allele in Acute Lymphoblastic Leukemia
Norfarazieda Hassan, Siti Zuleha Idris, Kian Meng Chang, Raudhawati Osman, Hishamshah Mohd Ibrahim, Jasbir Singh Dhaliwal, Maha Abdullah * - Optimizing Patient Blood Management in Cardiac Surgery: A Systematic Review
Sultan Ghazzay Alotaibi *, Muneeb Ammar Alnouri, Rawaa Mahmoud Sulaiman, Abdulkhalek Abduljaleel, Ahmed Foad Bogari, Hani Nabeel Mufti - Evaluation of the Home Safety and Child-friendly Environment for Children with Bleeding Tendency Disorders
Fereshteh Karbasian, Maral Nikfarjam, Kiarash Noorizadeh, Ali Abbasi-Kashkooli, Peyman Eshghi, Hamid Reihani * - Type 2N von Willebrand Disease: Overcoming Diagnostic Challenges for Accurate Diagnosis
Behnam Azari, Minoo Ahmadinejad * - Molecular Pathways of Gliomas Involving RNA-Binding Protein Dynamics
Saman Batool *, Hamza Tanveer, Faisal Naeem, Asma Sarfaraz - Investigating the Dynamic Interplay Between Cellular Immunity and Tumor Cells in the Fight Against Cancer: An Updated Comprehensive Review
Seyed Ali Aghapour, Mehdi Torabizadeh, Seyed Sobhan Bahreiny, Najmaldin Saki, Mohammad Ali Jalali Far, Arshid Yousefi-Avarvand, Kiana Dost Mohammad Ghasemi, Mojtaba Aghaei *, Mohammad Mehdi Abolhasani, Mohammad Sharif Sharifani, Ehsan Sarbazjoda, Moslem Javidan - Impact of Low-Dose Alendronate Therapy on Target Joints in Hemophilia Patients in a Low-Income Country
Babak Abdolkarimi, Javad Rostami, Fatemeh Varehzardi, Shadi Tabibian *, Niki Panahi
Journal Information
- Journal Title: Iranian Journal of Blood and Cancer
- Publisher: Iranian Pediatric Hematology & Oncology Society
- Print ISSN: 2008-4595
- Online ISSN: 2008-4609
- Release interval: Quarterly
- Journal language: English
- Chairman: Dr. Mohammad Saeid Rahiminejad
- Editor-in-Chief: Dr. Hassan Abolghasemi
- Associate Editors: Dr.Davood Bashash; Dr. Mohammad Faranoosh
- Executive Editor: Amir-Mohammad Yousefi
- Current Issue: 2024، Volume 16، Number 2
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