Volume 14, Issue 3 ( September 2022 2022)                   Iranian Journal of Blood and Cancer 2022, 14(3): 32-40 | Back to browse issues page

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Tamaddon G, Fazeli P, saeidnia M, Farzi A, Pooresmaeil N, Javanmardi M H. Evans syndrome in the course of COVID-19 infection; Essentials and approaches. Iranian Journal of Blood and Cancer 2022; 14 (3) :32-40
URL: http://ijbc.ir/article-1-1216-en.html
Evans syndrome in the course of COVID-19 infection; Essentials and approaches
Gholamhossein Tamaddon * 1, Pooria Fazeli2 , Mohammadreza Saeidnia2 , Arghavan Farzi3 , Navid Pooresmaeil3 , Mohammad hamed Javanmardi2
1- Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. tamaddon.g@gmail.com , tamaddon.g@gmail.com
2- Shiraz Medical Sciences
3- Ilam Medical Sciences
Abstract:   (1246 Views)

Redundant studies proved coronavirus infection results from a defect in a suitable immune response that may exacerbate immune-inflammatory reactions like cytokine storm and autoimmunity. Evans syndrome (ES) is a rare chronic autoimmune disease that distinguishes it from autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP). Reports have shown significant differences in immune cells and laboratory parameters in Evans syndrome/COVID-19 co-infected patients. Also, the contribution between autoimmune diseases and SARS-CoV-2 infection could result in immune response disequilibrium that considers a possible mechanism for ES development. Moreover, we will briefly explain the double-edged sword role of immunosuppressive drugs in Evans syndrome/COVID-19 co-infected patients. Generally, the pathophysiology of SARS-CoV-2 in hematologic autoimmune disorders progression, particularly ES, remains unclear, but some investigations explain the COVID-19 infection mechanism in the mentioned disorders development. The purpose of the current study is to look at the coronavirus effects on Evans syndrome aggravation, the immune cells and laboratory markers alterations in Evans syndrome/COVID-19 co-infected patients, the coronavirus effects on Evans syndrome patients during their pregnancy, and the Evans syndrome / COVID-19 co-infected patient management.

Keywords: Coronavirus, COVID-19, Evans syndrome, Autoimmune disease, SARS-CoV-2
Full-Text [PDF 520 kb]   (1048 Downloads)    
: Review Article | Subject: Immunology
Received: 2022/01/12 | Accepted: 2022/08/16 | Published: 2022/09/19
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