Influences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia

Safaei, Akram; Zaker, F

Volume 4, Issue 4 (Summer 2012) Iranian Journal of Blood and Cancer 2012, 4(4): 169-178 | Back to browse issues page

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Safaei A, Zaker F. Influences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia. Iranian Journal of Blood and Cancer 2012; 4 (4) :169-178
URL: http://ijbc.ir/article-1-386-en.html

Influences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia

Akram Safaei ^*

, F Zaker

Abstract: (10565 Views)

Recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. To evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. The polymorphisms of genes encoding carcinogen-metabolizing enzymes (CYP family, NQO1, GST), enzymes involved in folate metabolism (MTHFR, MTRR, SHMT, TS), and DNA repair enzymes (RAD51, XRCC1, ERCC2), chromosome translocation and epigenetic events discussed in this review, can be introduced as candidate alterations in acute lymphoblastic leukemia. Keyword: Acute lymphoblastic leukemia, genetic predisposition to disease, DNA repair enzymes, translocation, review.

Keywords: Keyword: Acute lymphoblastic leukemia, genetic predisposition to disease, DNA repair enzymes, translocation, review.

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: Original Article | Subject: Pediatric Hematology & Oncology
Received: 2012/01/8 | Accepted: 2012/04/9 | Published: 2013/03/14

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