Rostami S, Pourmokhtar M. In vitro Evaluation of the antibacterial activity of Platelet-rich Plasma against Selected Oral and Periodontal Pathogens. Iranian Journal of Blood and Cancer 2018; 10 (2) :35-38
URL:
http://ijbc.ir/article-1-789-en.html
1- Department of Pharmaceutics, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran/ Iran
2- Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran/Iran , mpourmokhtar@gmail.com
Abstract: (3943 Views)
Background: Despite the availability of a wide range of antibiotics, bacterial infections are among important challenges for the healthcare system. Therefore, the introduction of new antimicrobial preparations such as platelet-rich plasma (PRP) could be suggested theoretically as a preventive measure for bacterial infections. We aimed to evaluate the in vitro antibacterial activity of PRP against three common oral bacteria.
Methods: In vitro antibacterial activity of PRP against Streptococcus Mitis, Streptococcus Mutans, and Neisseria Lactamica as three common oral/dental bacteria was determined by disc diffusion method. Baseline antibacterial activity was assessed by measuring the diameter zone of inhibition after 24 hours of incubation at 37 °C.
Results: PRP had strong in vitro antibacterial activity against Streptococcus Mitis, Streptococcus Mutans and Neisseria Lactamica with the mean zone of inhibition diameters of 6.73±0.52, 5.8±0.43 and 6.67±0.43 mm, respectively.
Conclusion: PRP is an effective antibacterial agent along with conventional antibiotic treatments against oral and periodontal infections.
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Original Article |
Subject:
Infectious Diseases Received: 2018/02/28 | Accepted: 2018/04/21 | Published: 2018/08/26